Last updated 2026-07-26
TL;DR
There's no clinically validated Selank dosage calculator, human or automated. Russian studies used 250 to 3000 mcg/day, mostly split into 2-3 nasal doses over 10-14 days. Most people extrapolate from a 0.15% spray (about 75 mcg per spray) rather than trust any online tool. Treat every calculator, including math below, as an estimate layered on thin evidence.
Is there an actual validated Selank dosage calculator?
No. There's no peer-reviewed, government-vetted, or manufacturer-issued calculator for Selank dosing. What you'll find online (including tools that call themselves "calculators") are just unit converters: they take a spray's stated concentration, a bottle volume, and spit out mcg per spray. That's arithmetic, not pharmacology. The honest starting point is Russian clinical literature, most of it from the Institute of Molecular Genetics and related Moscow research groups, where Selank was studied as an anxiolytic peptide in the 1990s and 2000s [1]. Those trials used doses ranging from 250 mcg to 3000 mcg per day, split across two to three intranasal administrations, typically for 10 to 14 days [1][2]. There's no FDA-reviewed dose-finding study behind any of this. The number you land on with a calculator is only as good as the assumption you feed it, and the assumption is always "a Russian trial from decades ago is analogous to your situation," which may or may not be true. If you want the deeper backstory on what those trials actually showed and how strong the evidence really is, that's covered on the main selank page.
How do you calculate Selank dose from a nasal spray bottle?
Most people who use Selank use a 0.15% intranasal solution, and the math is simple once you know the concentration. A 0.15% solution means 1.5 mg (1500 mcg) of Selank per mL of liquid. A standard spray pump delivers about 0.1 mL per actuation, which works out to roughly 150 mcg per spray at 0.15% concentration, though many commercial sprays are formulated closer to 0.075% to 0.1%, which lands nearer 75 to 100 mcg per spray. Always check the labeled concentration on the specific product, because this varies by supplier. Here's the formula: mcg per spray = (concentration in mg/mL) x 1000 x (spray volume in mL) Example: 0.15% solution = 1.5 mg/mL. At 0.1 mL per spray: 1.5 x 1000 x 0.1 = 150 mcg per spray. If a Russian trial protocol called for 900 mcg/day [2], that's roughly 6 sprays a day at 150 mcg each, or split across two sessions of 3 sprays. This is where a calculator earns its keep: converting concentration and volume into a spray count. It cannot tell you whether 900 mcg/day is right for you, because that number came from a specific trial population and endpoint, not from a dose-response curve validated for general use. For the full walkthrough on splitting doses across a day and adjusting for body weight, see selank dosage.
What doses did Russian Selank studies actually use?
| Anxiolytic effect, human trial protocol | 900 mcg/day (300 mcg x 3) | 14 days | [2] | |
|---|---|---|---|---|
| General anxiolytic/nootropic range cited in reviews | 250-3000 mcg/day | Varies, often 10-14 days | [1] | |
| Animal model studies (rodent) | Weight-based, mg/kg, not directly convertible to human mcg | Varies | [3] | That last row matters. A lot of the foundational pharmacology on Selank (mechanism, half-life behavior, receptor interaction) comes from rodent studies dosed in mg/kg, which cannot be cleanly scaled to a human mcg dose without assumptions most calculators quietly skip. If a tool gives you a number without telling you which study it borrowed from, that's a red flag, not a feature. |
The dose range in published Selank research is wide, which itself tells you something: nobody has nailed down a single "effective dose." A commonly cited protocol used 900 mcg/day for treatment of generalized anxiety disorder symptoms, administered as 300 mcg three times daily for two weeks [2]. Other studies describing Selank's anxiolytic and nootropic effects in animal and early human work used doses spanning 250 mcg up to 3000 mcg/day [1][3]. Table: Doses reported across Selank literature | Use case (as described in source) | Reported dose | Duration | Source |
How much Selank should you take per day?
There's no dose backed by Western regulatory review, so any number here is a description of common practice layered on Russian trial ranges, not a recommendation with FDA-level backing. Most people who use Selank based on the published literature land somewhere between 250 and 900 mcg/day, split into two or three intranasal doses. A reasonable, honest way to think about it: the 900 mcg/day, three-times-daily protocol is the most frequently cited human dosing regimen in the literature [2], so it's the default a lot of people start from. Higher doses (up to 3000 mcg/day) appear in some sources but are less consistently described and less replicated [1]. What nobody has good data on: dosing for otherwise-healthy adults using Selank for everyday focus or stress rather than diagnosed anxiety, dosing intervals beyond 14 days, or how body weight should adjust the human dose. The trials that exist were short courses in specific patient populations. Extrapolating to "take this daily for months" is exactly that: extrapolation, not evidence.
How does Selank dosage differ from Semax dosage?
People conflate these two peptides constantly because they come out of the same Russian research tradition and both get nasal-sprayed, but they are structurally and functionally different molecules with different dosing conventions. Selank is a synthetic heptapeptide derived from tuftsin, studied mainly as an anxiolytic with some nootropic claims [1]. Semax is a synthetic peptide derived from ACTH(4-10), studied mainly for cognitive and neuroprotective effects, including in post-stroke rehabilitation research in Russia [4]. Semax dosing in published protocols commonly runs lower on a per-spray basis, often cited around 250-1000 mcg/day depending on the indication studied, but the two shouldn't be dose-converted into each other. A calculator that lets you toggle between "Selank mode" and "Semax mode" using the same formula is oversimplifying two different pharmacological stories. If you're trying to decide between them or figure out whether stacking makes sense, the comparison breakdowns at semax vs selank and selank vs semax go through the mechanism and evidence differences in more depth than a dosing page can.
How many mcg are in one spray of Selank?
It depends entirely on the concentration of the specific product, and this is the single most common source of dosing confusion. There is no industry-standard concentration. Common concentrations seen in the market are 0.075%, 0.1%, and 0.15%, corresponding roughly to 75, 100, and 150 mcg per 0.1 mL spray, respectively. Always calculate from the labeled concentration and confirm the spray pump's delivered volume (some deliver 0.09 mL, some 0.1 mL, some 0.14 mL) rather than assuming a round number. A mismatch between assumed and actual spray volume is the easiest way to be off by 20-40% on your daily total without realizing it. If you're buying from a provider-reviewed source, the concentration and spray volume should be stated clearly on the product itself; if it isn't, that's a sourcing red flag worth taking seriously before you do any dosage math at all.
Do you need to adjust Selank dosage for body weight?
The human clinical literature on Selank does not report weight-adjusted dosing; doses are given as flat mcg/day amounts regardless of body size [2]. This is different from the animal literature, where doses are reported in mg/kg and do scale by weight [3]. That mismatch means there's no validated way to say "a 130-lb person should take X and a 220-lb person should take Y." Some people extrapolate proportionally from animal mg/kg data anyway, but that requires assumptions about interspecies dose scaling that pharmacologists use cautiously even in early drug development, and those assumptions haven't been validated for Selank specifically in a way that's been published. If a calculator asks for your weight and confidently outputs a personalized number, it's applying a formula that isn't backed by the human trial data that actually exists.
How long should a Selank dosing cycle last?
The most-cited human trial protocol used a 14-day course [2]. That's the duration with the clearest paper trail. Some sources describe courses as short as 10 days or as long as several weeks, but nobody has published long-term (months-long) human safety or efficacy data on continuous Selank use. A lot of people using Selank outside of a clinical trial context run it in cycles: two weeks on, then a break, loosely mirroring the 14-day protocol structure, then reassess. That's a reasonable, cautious pattern to borrow from the literature. What it is not is proof that longer continuous use is safe or that cycling improves outcomes; it's simply matching the only duration that's actually been studied and published.
What happens if you take too much Selank?
There isn't a well-characterized human overdose threshold in the published literature, and that absence is itself informative: it means nobody has run the kind of dose-escalation safety study that would define one. Reported adverse effects in the existing literature at studied doses (up to 3000 mcg/day in some sources) are generally described as mild, but "mild in a short trial at a monitored dose" is not the same claim as "safe at any multiple of that dose." If you're worried about a specific dose you've taken, that's a poison control or medical question, not a calculator question. For a fuller rundown of documented and theoretical side effects at studied dose ranges, see selank side effects.
Should you trust an online Selank dosage calculator?
Trust the arithmetic, not the authority. Any calculator that converts concentration x volume into mcg per spray is doing real, checkable math, and you can verify it yourself with the formula above in about ten seconds. What you should not trust is a calculator that implies it knows the "right" dose for your body, your goal, or your duration of use, because that number doesn't exist in a form any tool can pull from a validated source. The most useful mental model: use a calculator (or the formula in this article) purely to translate a trial-reported dose (say, 900 mcg/day [2]) into a practical spray count for the specific concentration you've bought. Don't let a calculator invent a dose for you based on your weight, your stated anxiety level, or your goals, because none of the underlying literature supports that level of personalization.
Why is most of the Selank dosing evidence Russian, and does that matter?
Selank was developed and is still most extensively studied within Russian research institutions, and it has never gone through an FDA New Drug Application review or been the subject of a large-scale, peer-reviewed Western randomized controlled trial published in a major international journal. That's not a minor caveat, it's the central fact anyone researching Selank needs to sit with. This doesn't mean the Russian literature is worthless. Some of it appears in indexed journals and describes real methodology, dosing protocols, and reported outcomes [1][2]. But it also means independent replication, the kind Western regulators and most clinicians would want before treating a dose as established, largely hasn't happened. When you see a specific number like "900 mcg/day" treated as authoritative, it's worth remembering that number traces back to a limited set of Russian studies, not a body of replicated international research. For sourcing that's transparent about this evidence gap rather than glossing over it, selank covers the studies in more depth, and Selank Co's own materials are explicit that the clinical case rests on Russian data that Western trials haven't replicated. If you're ready to buy, look for a provider-reviewed route rather than an anonymous retailer; Selank Co works with a named fulfilling pharmacy partner rather than compounding or manufacturing anything itself, which is the kind of chain-of-custody detail worth checking regardless of which source you use. More on vetting sources at buy selank.
Frequently asked questions
What is a normal starting dose of Selank?
Most people drawing on the published literature start around 250-300 mcg per dose, taken two to three times daily, mirroring the most-cited 900 mcg/day trial protocol [2]. There's no clinically validated "starting dose" for general use; this range simply reflects what's been studied, not what's been proven optimal for any individual.
How many sprays of Selank equal 900 mcg?
It depends on your spray's concentration. At roughly 150 mcg per spray (0.15% solution, 0.1 mL delivery), 900 mcg is about 6 sprays total, often split as 2 sprays three times a day. At 75 mcg per spray (0.075% solution), you'd need about 12 sprays total. Always check your product's labeled concentration first.
Can you use a Selank dosage calculator to figure out mg vs mcg?
Yes, that conversion is straightforward math: 1 mg equals 1000 mcg. If a product lists Selank content in mg per mL, multiply by 1000 to get mcg per mL, then multiply by your spray volume in mL. This part of any calculator is reliable; it's just unit conversion, not medical guidance.
Is there a difference between Selank and Semax dosing?
Yes. Selank and Semax are different peptides (Selank derived from tuftsin, Semax from ACTH(4-10)) studied for different primary effects, anxiolytic versus cognitive/neuroprotective, respectively [1][4]. Published dosing protocols differ between them, so you can't take a Selank dose calculation and apply it directly to Semax or vice versa.
Does body weight change how much Selank you should take?
The human trial literature doesn't report weight-adjusted Selank dosing; published protocols use flat mcg/day amounts regardless of body size [2]. Animal studies use mg/kg dosing, but scaling those to human weight-adjusted doses involves assumptions that haven't been validated specifically for Selank in published human research.
How long can you safely use Selank at a given dose?
The clearest published protocol runs 14 days [2]. There's no published long-term human safety data for continuous use beyond that window, so anyone using it longer is extrapolating past what the literature actually covers, not following an established, studied duration.
What's the maximum Selank dose used in studies?
Some sources describe doses up to 3000 mcg/day in the broader literature on Selank's anxiolytic and nootropic effects [1], though the most frequently cited and better-documented human protocol used 900 mcg/day [2]. Higher-end figures appear less consistently described across sources.
Is Selank FDA approved, and does that affect dosing guidance?
No. Selank has no FDA approval and has not gone through FDA-reviewed dose-finding trials. Dosing information available comes from Russian clinical and preclinical research, which means there's no regulator-vetted dosing label to defer to, unlike an approved prescription drug.
How do you calculate mcg per spray for a Selank nasal spray?
Multiply the concentration in mg/mL by 1000 to get mcg/mL, then multiply by the spray's delivered volume in mL. Example: a 0.15% solution (1.5 mg/mL) with a 0.1 mL spray delivers 150 mcg per spray. Check your specific product's label, since concentrations vary between 0.075% and 0.15% across suppliers.
Can you split a Selank dose throughout the day?
Yes, and most published protocols do exactly this: the commonly cited human trial used 300 mcg three times daily rather than one large daily dose [2]. Splitting doses across the day mirrors how the substance has actually been studied, rather than dosing once in a single large amount.
What happens if a Selank dosage calculator gives me a personalized number based on my weight or goals?
Be skeptical. No published human Selank research validates weight-based or goal-based dose personalization; trial protocols used flat mcg/day amounts for defined patient groups [2]. A calculator implying otherwise is applying an unvalidated formula, not citing evidence.
Where can I find reliable information on Selank side effects at different doses?
Check the dedicated breakdown of reported and theoretical adverse effects at studied dose ranges, which draws on the same Russian literature used for dosing protocols. See selank side effects for details on what's been documented and what hasn't.
Sources
- PubMed, Kolyasnikova KN et al., review discussing Selank pharmacology and dose ranges in anxiolytic/nootropic research: Selank dose ranges of 250 to 3000 mcg/day appear across the anxiolytic/nootropic research literature
- PubMed, Zozulya AA et al., clinical study of Selank in generalized anxiety disorder patients: 900 mcg/day (300 mcg three times daily) over 14 days is a commonly cited human dosing protocol for Selank
- PubMed, preclinical pharmacokinetic study of Selank in animal models (rodent, mg/kg dosing): Foundational Selank pharmacology data comes substantially from rodent studies dosed in mg/kg
- PubMed, Kolomin T et al., Semax peptide research on neuroprotective and cognitive effects, ACTH(4-10) analog: Semax is derived from ACTH(4-10) and studied mainly for cognitive and neuroprotective effects, distinct from Selank
- National Center for Biotechnology Information, Bookshelf, StatPearls entry on generalized anxiety disorder diagnostic criteria and treatment context: Generalized anxiety disorder, the condition studied in the cited Selank trial, is defined by specific diagnostic criteria relevant to interpreting trial populations
- U.S. Food and Drug Administration, 21 CFR 314.50, content and format of an NDA application (the review pathway Selank has not gone through): No FDA-reviewed dose-finding process has been conducted for Selank, unlike drugs that go through the standard U.S. NDA development and review process